A CASE OF A 61 YEAR OLD MAN WITH BICYTOPENIA UNDER EVALUATION






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A 61 year old male resident of Ramulapeta,yadadri dist who is a daily wage labourer in construction work came to the hospital with complaint of

CHIEF COMPLAINTS
Dry cough since 10 days
 Dragging pain towards the finger tips since 10 days
Lower back pain since 10 days
Shortness of breath Grade 2 -grade 3
Chest pain near heart since 10 days



 HISTORY OF PRESENTING ILLNESS
PATIENT WAS APPARENTLY ASYMPTOMATIC 3 YEAR AGO WHEN 
He noticed involuntary movements of upper right limb at rest and decreased on movement
2 years ago his wife passed away  because of which he became reclusive and increased intake of alcohol 
1 year back he noticed showing of moments and decrease in his pitch of voice
He has used medication but stopped using after 5 months due to lack of improvement of symptoms
Since 20 days back he has trouble recollecting and takes at least 30-40 minutes if he wants to do something
Like bringing a article from home

Then 10 days back he experienced dry cough 

Lower back pain on both sides draging type radiating towards the coccyx 
Parn in upper right arm radiating towards the finger tips dragging in nature 
Both of which were relieved on medication and rest

Chest pain more of a burning sensation since 10 days 

Shortness of breath Grade 2 -3
Not relieved on rest 
No association with  vomiting or headaches



PAST HISTORY

10 days back had a episode of fever which subsided on medication
Not a known case of
Diabetes 
Hypertension
Tb 
Asthama
Epilepsy
Cvd
Chemotherapy

FAMILY HISTORY
Not significant

PERSONAL HISTORY
Diet - mixed
Appetite - Decreased 
Bowel and bladder - adequate
Allergies -no
Addiction - after demise of wife he sought these
18 ciggarette per day and alcohol

Daily routine before 10 days
5:00 woke up
6-7:00 had breakfast
9:30 went to work
1:00 lunch
6:30_7:00 comes back and watches tv
8-9:00 dinner
9:30 sleep

Daily routine after pain
Stopped going to work
Still wakes up at 5  but then 
Eats and sleeps 
Sometimes watches tv


GENERAL EXAMINATION
Thin built and malnourished 

Vitals
Temperature : Afebrile 
Pulse: 81
BP:110/80 mm/ hg
RR :18 
SPO2 : 97%


Pallor : present 


Icterus present
Clubbing absent
Cyanosis absent
Lymphadenopathy absent
Pedal edema absent
JVP RAISED 





SYSTEMIC EXAMINATION
CVS
Apex beat 6 th intercoastal space
No thrills
S1 S2 heard
No murmurs

RESPIRATORY SYSTEM


No dyspnoea wheeze
Central trachea 
Bilateral air entry +
Bilateral basal crepts +


ABDOMEN
Soft

Non tender



CNS
Higher functions
Patient is conscious, coherent,and co operative
Patient is oriented to place not to time and person
Delay in response but able to recall

Crainal nerve intact



Examination of motor system 
Tone increased on right upper limb
Not able to approximate both upper limbs
Power of muscle normal

Coordination of movement 

Tremors : resting
                 pill rolling movement
Reflex

Sensory system
Normal

INVESTIGATION


Day 1 
Day 3

Day 4

Day 5





Day 6


Day 7



Day 8


Day 9













Peripheral blood smear on 8th


Peripheral blood smear on 10th

Peripheral blood smear On 11th



PROVISIONAL DIAGNOSIS
BICYTOPENIA  SECONDARY TO PLASMA CELL DYSCRACIA
WITH
COMMUNITY ACQUIRED PNEUMONIA WITH (BILATERAL LOWER LOBE CONSOLIDATION)
WITH 
MODERATE HEPATOSPLEENOMEGALY
WITH
HYPONATREMIA (RECOVERED )2 TO SIADH? 
ALTERED MENTATION




Day 1

S :- 
Patient is having resting tremors
Delayed speech
Altered sensorium

O:-
Pt is conscious, coherent cooperative

Bp:-140/70
Pr:-92 bpm
Cvs:-s1s2+
R/s:-BLAE +
P/A:- soft , non tender spleenomegaly
CNS:- NAD

A:-
BICYTOPENIA UNDER EVALUATION
WITH
 COMMUNITY ACQUIRED PNEUMONIA WITH PARKINSON'S(?)WITH 
MODERATE SPLEENOMEGALY

P:-
Inj AUGMENTIN 1.2g/IV/BD
TAB AZITHROMICIN 500 mg/PO/OD
INJ OPTINEURON 1 amp 100 ml /NS
Vital monitoring
Temperature monitoring


Day 2

S :- 
Patient is having resting tremors
Delayed speech

O:-
Pt is conscious, coherent cooperative

Bp:-120/70
Pr:-93 bpm
Cvs:-s1s2+
R/s:-BLAE +
P/A:- soft , non tender spleenomegaly
CNS:- NAD

A
BICYTOPENIA UNDER EVALUATION
WITH
 COMMUNITY ACQUIRED PNEUMONIA WITH PARKINSON'S(?)WITH 
MODERATE SPLEENOMEGALY

P:-
Inj AUGMENTIN 1.2g/IV/BD
TAB AZITHROMICIN 500 mg/PO/OD
INJ M6RVIG6M1000 micrograms//IV/OD IN 50 ML NS
INJ OPTINEURON 1 amp 200 ml /NS
Vital monitoring
Temperature monitoring

Day 3

S :- 
Patient is having resting tremors
Delayed speech
O:-
Pt is conscious, coherent cooperative

Bp:-110/80
Pr:-86 bpm
Cvs:-s1s2+
R/s:-BLAE +
P/A:- soft , non tender spleenomegaly
CNS:- NAD

A:-BICYTOPENIA UNDER EVALUATION
WITH
 COMMUNITY ACQUIRED PNEUMONIA WITH PARKINSON'S(?)WITH 
MODERATE SPLEENOMEGALY

P:-
Inj AUGMENTIN 1.2g/IV/BD
TAB AZITHROMICIN 500 mg/PO/OD
INJ M6RVIG6M1000 micrograms//IV/OD IN 50 ML NS
TAB PANTOPRAZOLE 40 MG/PO/OD
Vital monitoring
Temperature monitoring

Day 4

S :- 
Patient is having resting tremors
Delayed speech
O:-
Pt is conscious, coherent cooperative

Bp:-110/80
Pr:-86 bpm
Cvs:-s1s2+
R/s:-BLAE +
P/A:- soft , non tender spleenomegaly
CNS:- NAD

A:-BICYTOPENIA UNDER EVALUATION
WITH
 COMMUNITY ACQUIRED PNEUMONIA WITH PARKINSON'S(?)WITH 
MODERATE SPLEENOMEGALY

P:-
Inj AUGMENTIN 1.2g/IV/BD
TAB AZITHROMICIN 500 mg/PO/OD
INJ M6RVIG6M1000 micrograms//IV/OD IN 50 ML NS
TAB PANTOPRAZOLE 40 MG/PO/OD
Vital monitoring
Temperature monitoring





Day 5
S :- 
Patient is having resting tremors
Fever spikes
Shortness of breath
Pain at bone marrow biopsy site
Delayed speech
O:-
Pt is conscious, coherent cooperative

Bp:-110/70
Pr:-92 bpm
Cvs:-s1s2+
R/s:-BLAE +
P/A:- soft , non tender spleenomegaly
CNS:- NAD

A:-BICYTOPENIA UNDER EVALUATION(2 to malignancy infection) 
WITH
 COMMUNITY ACQUIRED PNEUMONIA WITH ESSENTIAL TREMORS WITH 
MODERATE SPLEENOMEGALY

P:- 
TAB AZITHROMICIN 500 mg /PO/OD
TAB ULTRACET1/2tab /QID
TAB PANTOPRAZOLE 40 MG/PO/OD
INJ PIPTAS 4.5gm /IV/TID
TAB ZINCOVIT OD/PO
Vital monitoring
Temperature monitoring




Day 6
S :- 
Patient is having resting tremors
Pain at bone marrow biopsy site
Delayed speech
O:-
Pt is conscious, coherent cooperative

Bp:-120/80
Pr:-98 bpm
Cvs:-s1s2+
R/s:-BLAE +
P/A:- soft , non tender spleenomegaly
CNS:- NAD

A:-BICYTOPENIA UNDER EVALUATION(2 to malignancy infection) 
WITH
 COMMUNITY ACQUIRED PNEUMONIA WITH ESSENTIAL TREMORS WITH 
MODERATE HEPATOSPLEENOMEGALY

P:- 
TAB DOLO 650 mg /PO/OD
TAB ULTRACET1/2tab /QID
TAB PANTOPRAZOLE 40 MG/PO/OD
INJ PIPTAS 4.5gm /IV/TID
TAB ZINCOVIT OD/PO
Vital monitoring



Day 7

S :- 
Patient is having resting tremors
Altered behavior GCS E4V4M4
Involuntary Micturation
Fever spikes
Pain at bone marrow biopsy site
Delayed speech
O:-
Pt is conscious

Bp:-110/60
Pr:-130 bpm
Cvs:-s1s2+
R/s:-BLAE +
P/A:- soft , non tender spleenomegaly
CNS:- NAD

A:-BICYTOPENIA UNDER EVALUATION(2 to malignancy infection) 
WITH
 COMMUNITY ACQUIRED PNEUMONIA WITH ESSENTIAL TREMORS WITH 
MODERATE HEPATOSPLEENOMEGALY

P:- 
Riley's tube
Foleys catheter
IVF 3% Nacl at 10ml/hr
INJ MEROPENUM 1g IV STAT
INJ MEROPENUM 1g IV/BD
Temperature charting
Vital monitoring
Ryles feed



Day 8
S :- 
Patient is having resting tremors
Altered behavior
Fever spikes
Delayed speech

O:-
Pt is conscious

Bp:-130/70
Pr:-110 bpm
Cvs:-s1s2+
R/s:-BLAE +
P/A:- soft , non tender spleenomegaly
CNS:- NAD
Kerning sign positive

A:-BICYTOPENIA UNDER EVALUATION(2 to malignancy? infection? ) 
WITH
 COMMUNITY ACQUIRED PNEUMONIA WITH ESSENTIAL TREMORS WITH 
MODERATE SPLEENOMEGALY
ACUTE SYMPTOMATIC HYPONATREMIA 2 TO SIADH? 
ALTERED SENSORIUM 2 TO HYPONATREMIA? MENINGITIS? 

P:- 
Riley's tube
Foleys catheter
IVF 3% Nacl at 10ml/hr
INJ MEROPENUM 500 mg IV/BD
INJ OPTINEURON 1 AMP IN 100 ml NS/IV/OD
INJ NEOMOL 1 gm IV/SOS
TAB DOLO
Temperature charting
Vital monitoring
Ryles feed



Day 9
S :- 
Patient is having resting tremors
Altered behavior
Fever spikes
Delayed speech

O:-
Pt is conscious

Bp:-110/60
Pr:-120 bpm
Cvs:-s1s2+
R/s:-BLAE +
P/A:- soft , non tender spleenomegaly
CNS:- NAD
Kerning sign positive

A:-BICYTOPENIA UNDER EVALUATION
WITH PLASMA CELL DYSCRCIA
 COMMUNITY ACQUIRED PNEUMONIA WITH ESSENTIAL TREMORS WITH 
MODERATE SPLEENOMEGALY
ACUTE SYMPTOMATIC HYPONATREMIA 2 TO SIADH? 
ALTERED SENSORIUM 2 TO HYPONATREMIA? MENINGITIS? 

P:- 
Riley's tube
Foleys catheter
IVF 3% Nacl at 10ml/hr
INJ MEROPENUM 500 mg IV/BD
INJ OPTINEURON 1 AMP IN 100 ml NS/IV/OD
INJ NEOMOL 1 gm IV/SOS
TAB DOLO
Temperature charting
Vital monitoring
Ryles feed

DISCHARGE SUMMARY











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